In fact, the finding of abnormal glucose homeostasis in the knockout mice for Fem1b gene, the identification of a germline missense mutation in FEM1A gene in a PCOS patient and the observation of FEM1A being downregulated in human Rhabdomyosarcoma cell lines, support this hypothesis [8,9,39]. The gene discussed is FEM1B; the disease is polycystic ovary syndrome.