S100A8 and gastric cancer: In summary, the decline in gastric cancer observed during modernization across developed nations [1,5] may reflect not only the progressive disappearance of H. pylori [12], especially cagA+ strains [13], but, as transmission becomes less intense, this may reflect a change in the average age of acquisition [11], in the number of different strains acquired [47], or in their preadaptation to particular hosts [42,43].