Such salt-losing forms of adrenal insufficiency causing combined glucocorticoid and mineralocorticoid insufficiency can occur in several well-defined conditions, such as defects in steroidogenesis (e.g. steroidogenic acute regulatory protein (STAR), CYP11A1, HSD3B2, CYP21), following adrenal destruction (e.g. haemorrhage, adrenoleukodystrophy, autoimmune), or with forms of congenital adrenal hypoplasia (e.g. X-linked (DAX1), steroidogenic factor-1, IMAGe).22,23. Here, NR0B1 is linked to Decreased circulating aldosterone concentration.