Spark et al. reported an impaired aldosterone response to ACTH stimulation in a patient with FGD, but the molecular diagnosis is not reported.24 Furthermore, this patient presented in childhood with isolated glucocorticoid insufficiency, no clinical disturbances in the renin-angiotensin-aldosterone pathway were ever detected, and an impairment of aldosterone response to ACTH stimulation was only evident in the recumbent setting when the individual was assessed in early adulthood. This evidence concerns the gene POMC and Aarskog-Scott syndrome, X-linked.