In particular, the upregulation of cytokines and corresponding receptors within the common γ chain receptor family (particularly IL-15 and the IL-15 receptor α-chain, the IL-2/IL-15 receptor β-chain and the common γ chain itself; Figure 3b) suggest early activation within the tumor microenvironment of CD8 T and NK cells [15,16]. Here, CD8A is linked to neoplasm.