BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Interesting candidates in these regions include the BCR gene, implicated in chronic myeloid leukemia and acute myeloid leukemia; the RGR oncogene involved in RAS-signaling [58] and found to be altered in human T-cell malignancies [42]; and the zinc finger protein encoding gene ZCWCC1. One additional candidate region starts at clone ID 390 and extends toward the telomere (Fig 1A).