BRCA2 and breast carcinoma: Cumulative risk for this malignancy was assessed in 164 BRCA2-BCLC families, which included 59 cases of male breast cancer, and risk was estimated at 2.8% (95% CI 0.6–13.0%) by age 70 years, rising to 6.9% by age 80 years (95% CI 1.2–38.6%) (Thompson and Easton 2001).