BRCA1 and familial pancreatic carcinoma: In BRCA1 carriers pancreatic cancer risk carriers by age 70 years has been estimated to be 1.16% (95% CI 0.83–1.61%) in men, and 1.26% (95% CI 0.92–1.72%) in women, reflecting a two-fold RR (Thompson and Easton, 2002).