PPP1R13B and leukemia: Furthermore, in leukaemia cancer cell lines a concomitant downregulation of ASPP1 with an upregulation of iASPP has been observed, suggesting that abnormal ASPP expression could be an important step in the formation of human haematopoietic neoplasms and might be a useful molecular marker for the diagnosis of leukaemia (Liu et al, 2004).