Zyxin gene transfer into EWS-FLI1-transformed fibroblasts elicits reconstitution of zyxin-rich focal adhesions and leads to decreased cell motility and inhibition of anchorage independent tumour growth, indicating that zyxin has tumour suppressor activity in these cells (Amsellem et al, 2005). The gene discussed is EWSR1; the disease is neoplasm.