Interestingly, recent work has shown, that knock-down of LASP-1 in metastatic breast cancer cell lines BT-20 and MCF-7 results in a strong inhibition of proliferation and migration and leads to a reduction of zyxin at focal contacts through absence of LASP-1 (Grunewald et al, 2006). The gene discussed is ZYX; the disease is breast carcinoma.