MME and metastatic melanoma: Clinicopathologic correlation with NEP overexpression in metastatic melanoma samples revealed no significant association between increased NEP expression and age (27% of subjects ≤ 65 years-old overexpressed NEP versus 40% of subjects >65 years-old, p = 0.34) or gender (40% of females versus 25% of males overexpressed NEP, p = 0.24).