LAPTM4B and cancer: Specifically, a number of the genes identified have been found to be overexpressed in melanoma and other cancers, including glutathione S transferase pi, which is overexpressed in melanoma, and is thought to play a role in melanoma drug resistance [28], and lysosomal associated protein transmembrane 4 beta, which is overexpressed in numerous solid tumors such as hepatocellular carcinoma, lung cancer and colon cancer, and has been shown to increase proliferation rates and anchorage independent growth in tumor cell lines [29,30].