PPARG and tic disorder: PANDAS, a pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections is defined by obsessive-compulsive (OCD) and or tic disorders, is thought to be due to the actions of auto-immune antibodies on basal ganglia neurons [60], and is improved by immunomodulatory therapies [61]; anti-inflammatory effects of PPARγ agonists could therefore influence the course of this disease.