Recently however, some papers have shown correlation of high expression of FoxP3 and low or no expression of IL-7R alpha CD127low/- on the cell surface[13], [14] Humans without functional FoxP3 protein have an autoimmune disorder called IPEX with auto-antibodies against a diversity of organs[15]. The gene discussed is FOXP3; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.