CD4 and type 1 diabetes mellitus: Of great interest, while FoxP3+ve and FoxP3-ve CD4+CD25+high T cells in both control and longstanding T1D subjects did not show differences in the apoptosis rate, FoxP3+ve CD4+CD25+high in recent-onset T1D subjects were significantly more apoptotic than FoxP3-ve CD4+CD25+high T cells from the same individual Figure 4, p = 0.01.