The predicted prognostic subtypes based on our three-stage class-prediction method showed strong association with the status of ER expression, histo-pathological grade [14], 70-gene signature prediction [2], [3], core serum-response signature [15], [16] and ERBB2 signature [17] but not with age, tumor size, the number of positive lymph nodes or treatment (Table 1). The gene discussed is ESR1; the disease is neoplasm.