The over-expression of fibulin-1D in fibrosarcoma-derived cells reduced anchorage-independent growth in vitro, in addition to delayed tumor formation in vivo[38], moreover, both ectopically expressed fibulin-1D and purified fibulin-1 protein have been shown to inhibit the cell adhesion, spreading, motility and invasion of a range of human tumor-cell lines in vitro[39]. The gene discussed is FBLN1; the disease is neoplasm.