TNFRSF1A and Bloom syndrome: Mice lacking TNFR signaling in either non-hematopoietic (WT to tnfR−/−) or hematopoietic (tnfR−/− to WT) compartments were capable of eliciting an inflammatory response to BLM (Fig. 9 A,B) composed mainly of macrophages (Fig. 9D).