With LowCa, SBP was lower after 60% VO2max among those less predisposed to cardiovascular disease risk based upon RAS genotype, i.e. ACE I allele carriers and AT1R AA homozygotes; and after 40% VO2max among those more predisposed to cardiovascular disease risk based upon their RAS genotype, i.e., ACE DD homozygotes and carriers of the AT1R C allele [17,18]. Here, ACE is linked to cardiovascular disorder.