NCF1 and Lewy body dementia: Several major observations were made in this study, including: 1) microglia isolated from EP2-/- microglia exhibited enhanced clearance of aggregated α-synuclein from the tissue sections of patients with Lewy body disease; 2) mice without EP2 were more resistant to neurotoxicity induced by MPTP, and this effect was seen in association with attenuated formation of aggregated α-synuclein in the SN and striatum; and 3) EP2-/- microglia exposed to aggregated α-synuclein appeared to have less membranous translocation of p47-phox, a critical process leading to PHOX activation.