It is also worth noting that in several instances the frequency of disease-associated and other alleles have been shown to be markedly different between Caucasian and Asian populations [35,36] including alleles associated with RA and other auto-immune conditions [37], therefore, our observed differences in the allele frequency of VEGF +936 (rs3025039) from other published reports is not surprising. Here, VEGFA is linked to rheumatoid arthritis.