Note that the tumor cell surface area, the vasculature surface area, and the interstitial volume all are central to the conversions, and thus changes to the geometry of the tissue (i.e., to these geometrical parameters) will result in changes to the effective kinetic parameters, and to the concentrations of VEGF and the complexes it forms with GAG chains or VEGF receptors. This evidence concerns the gene VEGFA and neoplasm.