For interstitial proteins, these equations are as follows:Here [V] represents the concentration of a VEGF isoform; [M] the concentration of VEGF binding sites in the ECM, EBM, or TBM; [R] the density of cell surface receptor tyrosine kinases; [N] the density of cell surface Neuropilin; qV,T is the secretion rate of VEGF from the tumor cells, and kon and koff are the kinetic rates of binding and unbinding, respectively. This evidence concerns the gene VEGFA and neoplasm.