For BNC1 and MSX1, both prostate and colon benign tissues did have some methylation, but the pattern was different from CCNA1. ALDH1A3 was specifically methylated in all tumor types, albeit less frequently than BNC1 or MSX1, showing the highest sensitivity in breast and prostate and highest specificity in lung. The gene discussed is ALDH1A3; the disease is neoplasm.