Basonucleolin (BNC1) and lysyl oxidase (LOX) were methylated in nearly all of the primary tumors examined, but were not methylated in normal PBCs, and infrequently in normal lung; in comparison, p16 and RASSF1A were methylated in this same NSCLC panel at rates of 30% and 40%, respectively [18]. Here, BNC1 is linked to non-small cell lung carcinoma.