However, two well-characterized tumor suppressors, p16 and RASSF1A, exhibit similar tumor-specific and tissue-specific promoter methylation profiles; p16 methylation is frequently observed in benign breast tissue, even in young women, and RASSF1A promoter hypermethylation is observed in benign liver and colonic epithelium [45,58]. Here, RASSF1 is linked to neoplasm.