IRS1 and cancer: Notably, several genes have been reported to be associated with cancer survival (APC, IRS1, SLC2A1, BCL2, ABCC1, FLT3, RAD9A, Inhibin A, NTRK3, CASP8, and CASP10). The APC gene plays a role in NSCLC, and high APC promoter methylation is significantly associated with poor survival in NSCLC [19].