This result is in line with observations that HLA-A*0201-restricted CTL clones against HPV-16 E629–38 that recognize HPV-16 E6 antigens transfected into B lymphoblastoid cells are unable to recognize HLA-A*0201(+) HPV16 E6(+) cervical carcinoma cell lines even when the level of endogenous HPV-16 E6 in these cells was increased by transfection. The gene discussed is HLA-A; the disease is cervical carcinoma.