So, our data may suggest that some cases of pseudotumor cerebri may recognise a thrombotic pathogenesis; although based on a small population, our results, in fact, seem to underline a clear association between hypercoagulable state, confirmed both with markers of hypercoagulability (i.e. fibrinopeptide A, prothrombin fragment 1+2 and D-Dimer) and with tests to look for inherited thrombophilia (i.e. factor V Leiden, prothrombin A20210G, PAI 4G/5G, ACE I/D, MTHFR C677T). This evidence concerns the gene SERPINE1 and pseudotumor cerebri.