Further evidence for this concept was recently obtained by Bresson et al., who showed that combination of peptide therapy with anti CD3 enhanced the clinical improvement in experimental diabetes compared to anti-inflammatory therapy alone, also through the induction of CD25+FOXP3+ Tregs, as well as insulin specific Tregs producing IL-10 and TGFβ[47]. The gene discussed is TGFB1; the disease is diabetes mellitus.