Although Rps19 knockout mice (Rps19−/−) have been developed [10], they are not useful as a DBA model because Rps19−/− zygotes do not form blastocysts, whereas Rps19+/− mice show normal growth and organ development, including development of the hematopoietic system. The gene discussed is RPS19; the disease is Diamond-Blackfan anemia.