Functional gene ontology (GO) annotation analysis revealed that one of the most significantly over represented gene families in the invasive tumor stroma was annotated to the term endopeptidase activity and contained transcripts encoding proteolytic enzymes, including lysosomal proteases, asparaginyl endopeptidases, matrix metalloproteinases and proprotein convertases (Table S2). The gene discussed is LGMN; the disease is neoplasm.