Invasive CR2-TAg cancer stroma displayed induction of genes encoding numerous ECM proteins and ECM degrading enzymes, including ADAMTS4, MMP2, MMP3 CTSB, CTSC, CTSD and PLAUR. The combined substrate specificity of the induced proteolytic enzymes encompasses a broad range of ECM proteins, including collagens, fibronectin, fibrin, laminin and vitronectin, and latent growth factors, including among others, hepatocyte growth factor (HGF), TGF-β, and basic FGF [11], [24], [25]. The gene discussed is CTSD; the disease is cancer.