IGFBP3 and neoplasm: Thus, increased expression of genes encoding structural matrix components including, biglycan, procollagen type III, and IV, cartilage associated protein, regulators of insulin growth-factor bioavailability (IGFBP3), urokinase plasminogen activator receptor (PLAUR) and growth factor receptors (PDGFRB), may all play essential parts in the control of mesenchymal cell growth and differentiation, which may in turn influence tumor growth (Table 1).