Although a small previous study [20] found that carriers of the COX-2 .8473 variant C allele had a significantly increased risk for lung cancer (ORs 2.12 for CT genotype and 4.28 for CC genotype), an expanded study in the same population [28] failed to reproduce the association (ORs 0.96 for CT genotype and 0.97 for CC genotype). The gene discussed is PTGS2; the disease is lung cancer.