CDKN2A and cancer: In many cancer types, the most commonly hypermethylated genes are involved in DNA repair (hMLH1, MGMT), the cell cycle (p16INK4a, p15INK4b, p14ARF, SFN), apoptosis (DAPK), cell adherence (CDH1, CDH13) and detoxification (GSTP1) (Esteller, 2006).