A direct link between LANA and the de novo methyltransferase DNMT3a has been proposed in a study, that reveals that LANA recruits DNMT3a to the chromatin and targets repression of approximately 80 cellular genes, some of which are known targets of epigenetic inactivation in various cancers (Shamay et al, 2006). The gene discussed is DNMT3A; the disease is cancer.