The expression of podoplanin is upregulated in a number of different human cancers, including squamous cell carcinoma of the oral cavity, the larynx, the lung, the cervix, the oesophagus, and the skin, in dysgerminomas of the ovary and granulosa cell tumours, in mesothelioma, and in many tumours of the central nervous system (CNS) (Kato et al, 2005; Kimura and Kimura, 2005; Martin-Villar et al, 2005; Schacht et al, 2005; Shibahara et al, 2006; Wicki et al, 2006). This evidence concerns the gene PDPN and squamous cell carcinoma.