PDPN and breast cancer: In both human keratinocytes and in MCF7 breast cancer cells, the forced expression of podoplanin led to a dramatic change of cellular morphology with a significant decrease of cellular stress fibres and a concomitant formation of filopodia-like membrane protrusions, even in the presence of E-cadherin expression (Scholl et al, 1999; Wicki et al, 2006).