Oncogenes from other viruses can also induce hemangiomas and have helped elucidate a common pathway for hemangiogenesis that involves phosphatidylinositol 3-kinase (PI3K) activation, downstream activation of Akt, and increased vascular endothelial growth factor production; the latter being a key stimulus for hemangiogenesis. The gene discussed is AKT1; the disease is hemangioma.