However, subsequent studies showed that the acetyltransferase domain in CBP interacts with htt [78,80], which led to the finding that inhibition of histone deacetylase (HDAC) or promotion of histone acetylation ameliorates neurodegeneration in cellular and fly models [80] and motor deficits in a mouse model of HD [84]. Here, CREBBP is linked to Huntington disease.