Furthermore, information from RINGdb has shown both of RGS1 protein and its known binding partners, including Gα i1, Gα i2, Gα i3, Gα o1 and α-2A adrenergic receptor, are present in multiple sclerosis (MS) lesions, suggesting they may have a role in pathological conditions. This evidence concerns the gene RGS1 and multiple sclerosis.