We chose as a cell model a mouse adrenal tumor cell line (Y1-BS1 cells), which has certain desirable characteristics: i.e., cells with modest amounts of endogenous SR-BI, yet, like intact steroidogenic tissues, these cells have other essential cellular tools permitting hormone-stimulated steroid hormone (i.e., 20α-dihydroprogesterone) production. This evidence concerns the gene SCARB1 and adrenal gland neoplasm.