There is a strong correlation between genomic instability disorders with symptoms of progeria and premature senescence of the corresponding cultured fibroblasts, for example, in Werner syndrome, Hutchinson-Gilford progeria, and ataxia telangiectasia in humans [43], and BUB1, PASG, DNA-PK, ERCC1, and KU80 mutants in mouse [3]. Here, HELLS is linked to Werner syndrome.