Growth retardation, hypothermia, hypoglycemia (Figure 4A), and reduced body mass despite normal to increased food intake per gram body weight (Figure 1B) are phenotypes shared by long-lived mice with defects in growth hormone (GH) signaling, including GH-deficient Ames and Snell dwarfs and GH-resistant GH receptor (GHR) knock-out (GHR-KO) mice [31,32]. The gene discussed is GH1; the disease is Hypoglycemia.