TNFRSF18 and neoplasm: For example, Ko et al. [20] found FOXP3+CD25+CD4+ Tregs predominantly in growing tumors in mice that had not received an agonistic monoclonal antibody against glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR), thus suggesting that tumor-infiltrating natural Tregs may hamper effective tumor immunity.