In a study of 45 cancers, LOH at the FHIT locus 3p14.2 was found in five out of 45 (11%) of cancer-associated pre-neoplasia (grades not specified but included UDH, apocrine metaplasia, DCIS and intraductal papilloma) and 20 out of 44 (45%) cancers (Maitra et al, 2001). This evidence concerns the gene FHIT and ductal breast carcinoma in situ.