In a study involving 50 cancers, Gatalica et al (2000) found reduced FHIT protein expression in four out of 34 (12%) hyperplastic epithelium (grades not specified), 26 out of 47 (55%) atypical hyperplasia and DCIS combined and 33 out of 46 (72%) cancers. This evidence concerns the gene FHIT and ductal breast carcinoma in situ.