ASPH and sclerosing cholangitis: The peripheral distribution of prominent AAH immunoreactivity was not correlated with zonal differences in cell viability or proliferation [14], and correspondingly, proliferation states that were un-related to transformation, such as hepatocyte or bile duct regeneration, and pre-malignant conditions such as primary sclerosing cholangitis, were found to have low (normal) levels of AAH [11].