A cluster (Figure 4D) enriched for genes associated with the luminal/ER+ tumor subtypes (N-acetyltransferase 1, estrogen receptor 1, putative G-protein-coupled receptor, trefoil factor 3, GATA binding protein 3, and X-box binding protein 1) was also present in this gene set [2,11,12]. The gene discussed is ESR1; the disease is neoplasm.