We genotyped patients and controls for the following SNPs: Gly389Arg of ADRB1, Arg16Gly of ADRB2 (ADRB2-16), Gln27Glu of ADRB2 (ADRB2-27), G(-866)A of UCP2 and C(-55)T of UCP3. To consider the co-morbidity between obesity and T2DM the study participants were stratified according to BMI into obese (BMI>30 Kg/m2) or non-obese (BMI < 30 Kg/m2). This evidence concerns the gene ADRB2 and obesity due to melanocortin 4 receptor deficiency.