Ross et al (2003) confirmed the high prediction accuracy of 98% for AML with t(11q23)/MLL rearrangements in childhood AML. In addition, the authors could delineate APL with t(15;17)/PML-RARA, core-binding factor (CBF)-leukaemias, and acute megakaryocytic leukaemia with a 100% prediction accuracy in 130 children with AML. Here, KMT2A is linked to leukemia.