As to the association of antihypertensive drugs, 24 cases (33.3%) and 11 controls (23.9%) used more than one anti-hypertension drug, which prevailed among cases - 6 individuals (8.3%) and among the controls - 5 individuals (10.8%), with association of diuretic agents plus ACE inhibitors. The gene discussed is ACE; the disease is hypertensive disorder.