It is a acetylcholinesterase inhibitor similar to Galanthamine[9], a drug treating AD, and might be a low-molecular-weight neurotrophic drug to neurodegeneration disorder such as AD by potentiating the nerve growth factor (NGF)-induced differentiation in neural cells [10]; berberine is a novel cholesterol-lowering drug distinctly from statins by stabilizating the low density lipoprotein receptor (LDLR) mRNA to increase LDLR expression and inhibiting lipid synthesis[11,12]. Here, VLDLR is linked to Alzheimer disease.