In addition, in vitro experiments were conducted with the demethylating agents 5-Aza-CdR and zebularine to investigate their global growth inhibitory effects in different bladder (RT4, T24) and kidney cancer (A498, ClearCa-5) cell lines with p53 wild-type (RT4, A498) and p53 mutated (T24, ClearCa-5) status. Here, TP53 is linked to kidney cancer.