RAD21 is believed to function in sister chromatid alignment as part of the cohesin complex and also in double-strand break repair and influences cellular proliferation (Atienza et al, 2005), whereas EIF3S3 is reported to be amplified and overexpressed in up to 20% of breast carcinomas (Nupponen et al, 1999). This evidence concerns the gene RAD21 and breast carcinoma.