In addition to the MHC class II genes, other genes associated with survival direct the anti-tumor activity exerted by effector cells of the immune system such as T cells (TRA@, GZMK), NKT cells (CD1d) and B cells (IGLC2), confirming the notion that the clinical course of melanoma is closely associated with innate and acquired immune responses. The gene discussed is IGLC2; the disease is melanoma.