Of the genes correlated with shorter survival, some were already known to be over-expressed in different types of cancer, such as MCM3, BCHE [32,40-42], and some have previously been implicated in melanoma progression, like CSPG4 [43] and Cx26 [28] or, more generally, associated with tumor invasiveness, like ADAMTS5 [31]. The gene discussed is GJB2; the disease is melanoma.