For example, gene GJB2, encoding the gap junction protein connexin 26 (Cx26) a sub-type of gap junction proteins; gene CSPG4, coding for the melanoma-associated chondroitin sulfate proteoglycan 4; the disintegrin-like and metalloprotease genes with thrombospondin type 1 (ADAMTS5); the minichromosome maintenance 3 (MCM3) and the DCT genes, all whose expression by tumor cells is frequently associated with more invasive and metastatic behavior [27-33]. The gene discussed is ADAMTS5; the disease is melanoma.