There is also a clear association between c-erbB-2 positivity and worse nuclear and histological grades, tumor aneuploidy and high rate of proliferation, and this is more frequent in ductal carcinoma in situ than in invasive ductal carcinoma.5,18,19 This profile for c-erbB-2 protein expression is quite similar to the p53 protein expression profile.20,21. This evidence concerns the gene TP53 and ductal breast carcinoma in situ.