ZAP70 and neoplasm: To determine if the low levels of EGFP reporter expression obtained in Jurkat cells transduced with SINIL-2pr prior to drug stimulation were indeed a consequence of basal state of activation in this tumor T-cell line, we tested the SINIL-2pr design in Jurkat P116 T-cells that are deficient in ZAP-70, a kinase implicated in early steps in T-cell activation.