Since IGF-II is a positive regulator for proliferation in colon cancer cells [15], it is possible that overexpression of IGF-II may lead to a temporarily higher development of hyperplastic or atypical crypts, which are well detectable by methylene blue staining in the early stage of colon cancer development, but with a higher potential to regress [6]. The gene discussed is IGF2; the disease is malignant colon neoplasm.