VEGFD and neoplasm: In breast cancer, increased expressions of VEGF-C and VEGF-D in the tumour cells, both on the mRNA and protein level, are known to be associated with high LVD, lymphatic invasion and LN metastasis (Nakamura et al, 2003; Choi et al, 2005; Nakamura et al, 2005; Huang et al, 2006; Li et al, 2006).