For example, STARD3, PNMT, CAB2, C17ORF37 and GRB7 show a significant correlation between amplification status and expression level (Kauraniemi et al, 2001, 2003; Willis et al, 2003; Orsetti et al, 2004), and STARD3, PNMT, CAB2, GRB7 and ZNFN1A3 could all be biologically relevant to breast cancer. This evidence concerns the gene GRB7 and breast cancer.