MSH6 and colorectal neoplasm: Data from previous studies (Berends et al, 2002; Hendriks et al, 2004; Plaschke et al, 2004; Barnetson et al, 2006; Niessen et al, 2006) show that approximately 15% of colorectal tumours of MSH6 mutation carriers do not have an MSI-high pattern, whereas they do show loss of MSH6 expression and thus might be the result of the MSH6 germline mutation.